Our Publications
2021
“NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation.”
Andreeva L., David L., Rawson S., Shen C., Pasricha T., Pelegrin P., and Wu H.
Cell. 184(26):6299-6312.e6222“Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome.”
Shen C., Li R., Negro R., Cheng J., Vora S. M., Fu T.-M., Wang A., He K., Andreeva L., Gao P., Tian Z., Flavell R. A., Zhu S., and Wu H.
Cell. 184(23):5759-5774.e20“BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity.”
Bittner Z.A., Liu X., Mateo Tortola M., Tapia-Abellán A., Shankar S., Andreeva L., Mangan M., Spalinger M., Kalbacher H., Düwell P., Lovotti M., Bosch K., Dickhöfer S., Marcu A., Stevanović S., Herster F., Cardona Gloria Y., Chang T.H., Bork F., Greve C.L., Löffler M.W., Wolz O.O., Schilling N.A., Kümmerle-Deschner J.B., Wagner S., Delor A., Grimbacher B., Hantschel O., Scharl M., Wu H., Latz E., and Weber A.N.R.
J. Exp. Med. 218(11):e20201656“The cytosolic DNA sensor cGAS recognizes neutrophil extracellular traps.”
Apel F., Andreeva L., Knackstedt L.S., Streeck R., Frese C.K., Goosmann C., Hopfner K.-P., and Zychlinsky A
Sci. Signal. 4(673):eaax7942
2019
"Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome."
Sharif H., Wang L., Wang W. L., Magupalli V. G., Andreeva L., Qiao Q., Hauenstein A. V., Wu Z., Núñez G., Mao Y., and Wu H.
Nature 570(7761)
2017
“cGAS senses long and HMGB/TFAM bound U-turn DNA by forming protein-DNA ladders.”
Andreeva L., Hiller B., Kostrewa D., Lässig C., de Oliveira Mann C.C., Drexler D.J., Maiser A., Gaidt M., Leonhardt H., Hornung V., and Hopfner K.-P.
Nature 549(7672): 394-398
2015
“Sequence-specific activation of the DNA sensor cGAS by Y-form DaTNA structures as found in primary HIV-1 cDNA.”
Herzner A.M., Hagmann C.A., Goldeck M., Wolter S., Kübler K., Wittmann S., Gramberg T., Andreeva L., Hopfner K.-P., Mertens C., Zillinger T., Jin T., Xiao T.S., Bartok E., Coch C., Ackermann D., Hornung V., Ludwig J., Barchet W., Hartmann G., and Schlee M.
Nat. Immunol. 16(10):1025-33
2014
“Cytosolic RNA:DNA hybrids activate the cGAS–STING axis.”
Mankan A.K., Schmidt T., Chauhan D., Goldeck M., Höning K., Gaidt M., Kubarenko A.V., Andreeva L., Hopfner K.-P., and Hornung V.
EMBO J. 33(24):2937-46